GSK recently declared its intention to create the Accelerating Therapeutics for Opportunities in Medicine (ATOM) Consortium with the National Cancer Institute (NCI) and the U.S Department of Energy (DOE). This consortium aims to dramatically accelerate the discovery and development of drugs with an aspiration to go from target to first in human precision trials in twelve months or less. GSK, NCI, and DOE hope to achieve this goal by applying high performance computing modeling and simulation to large datasets that include information about structure and properties of existing and potential drug compounds. As part of GSK’s commitment to this initiative, the company has created several post-doctoral opportunities to work alongside industry and government scientists and be placed at the ATOM facility in San Francisco, CA.
One of these postdoctoral positions will be for a PhD level scientist with experience in pathway, whole cell and/or tumor level modeling. The incumbant will be part of a larger cross-functional consortium team at the ATOM facility, and together this team will be responsible for building and utilizing multi-scale mechanistic models to predict the pharmacokinetics, efficacy & safety liabilities (on/off target) of small molecule therapeutic candidates in healthy and diseased human systems. The models are intended to be used in virtual screens, integrated into multi-parameter active-learning based drug development workflows, and utilized in the ongoing development and validation of a quantitative pharmacology model for individual cancer patients.
This is an exciting opportunity to participate in an ambitious collaboration that will integrate high-performance computing, diverse biological data, and new approaches to molecular discovery in an exciting and energetic facility in the heart of San Francisco. Ultimately, the enablement of precision and accelerated discovery of therapeutics will expedite our ability to discover and develop novel medicines that will help patients do more, feel better and live longer.
Prioritize and develop pathway and whole cell models & technologies to accelerate the discovery and development of targeted therapeutics for Oncology with a high probability of success. If necessary, work with external partners to develop such models.
Provide high quality scientific and strategic guidance and recommendations to other ATOM scientists on complex in vitro models based on scientific merit, practicality and potential impact.
Collaborate with experimental scientists at the ATOM facility to further develop and validate mechanisms at the biochemical pathway, gene regulation and whole cell levels to rapidly integrate advanced biological data into the drug discovery process.
Work with the scientists throughout the ATOM facility to continuously optimize the Discovery process for generating therapeutics with a high probability of success in the shortest amount of time.
Advocate a culture of scientific challenge and peer review of existing complex in vitro models and of new technological opportunities to help ATOM eliminate the use of animal models and promote accelerated filing timelines.
Why You?Basic qualifications:
• Ph.D. in a scientific field, preferably computational biology, computational life sciences, computer aided drug discovery and/or statistical modeling.
• Proficient in one or more programming languages (e.g. Perl, C/C++, Java or Python, Ruby), and competent working in a Linux/Unix environment
• Experience with mechanistic or semi-mechanistic pathway, cell or organ/tumor level modeling.
• Inquisitive, creative and bold. Disruptive and innovative thinker that can deliver results.
• Excellent written and oral communication skills and the ability to interact effectively outside of the individual’s discipline.
• An ability to work and thrive in an extremely energetic, intellectual, fast-paced and matrix environment. Excellent interpersonal abilities, demonstrated inclusivity, flexibility and a history of working collaboratively in a team environment.
• Comfortable with risk, willing to fail, learn from it, and move on.
• High learning agility and a willingness to contribute at all levels of the ATOM group, including areas outside of the individual’s expertise.
• Knowledge of computational chemistry, computational molecular biology and molecular simulation is also desirable as is experience in multi-scale modeling from the atomistic level, through coarse graining all the way to entire cell models.
• Familiarity with computational/mathematical models to integrate available data and applying these to optimize/re-design the biological experiments is a plus.
• An understanding of how multiscale modeling fits into the modeling of human pharmacology of small molecule or antibody therapeutics.
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.
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