GlaxoSmithKline is committed to developing medicines for global health challenges including respiratory, immuno-inflammation, oncology and infectious diseases. We know that finding cures means not just finding new drugs, but finding new ways to discover drugs. One of our endeavors at GSK’s NCE Discovery site in Cambridge, MA, is developing screening technologies based on affinity selection – a discovery paradigm to screen unprecedented chemical diversity at a fraction of the time and cost of traditional methods. Our industry-leading platform based around DNA encoded small molecules (Encoded Library Technologies) is poised to achieve new levels of productivity following advances in selection methods, chemoinformatics, and high throughput chemistry. We are looking for experienced medicinal chemists to integrate the output of ELT selections into a strategy for pipeline progression. Experience with analyzing and interpreting large data sets is desired. The successful candidate will interface with business partners on therapeutic area program teams to conceive, articulate, and execute on the strategy. and technology advances.
For further information see the following references:
Clark et al Design, Synthesis and Selection of DNA-Encoded Small-Molecule Libraries. Nat. Chem. Biol. 2009, 5, 647-654.
Arico-Muendel. From haystack to needle: finding value with DNA encoded library technology at GSK. MedChemComm 2016, 7, 1898-1909. DOI:10.1039/c6md00341A
Machutta & Kollmann et al. Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening. Nat. Commun. 2017, 8, 16081. DOI:10.1038/ncomms16081
Why You?Basic qualifications:
• PhD in organic or medicinal chemistry with 3 years of medicinal chemistry experience in the pharmaceutical industry
• Expert in synthetic organic chemistry methods and analytical tools
• Independent in lab work, data analysis, and interpreting / presenting results
• Track record of success demonstrated through publication, patent, or presentation
• Excellent skillset and use of computational tools
• Outgoing personality with track record of working in a matrix setting
• Ability to multitask and experienced in collaborating across disciplines
• Excellent oral and written communications
• Expertise in medicinal chemistry with track record in small molecule Hit to Lead and Lead Optimization processes.
• Experienced in use of cheminformatics and other computational tools for drug design
• Desire to lead initiatives in platform building
• Demonstrated ability to learn and influence outside of core area of expertise
• Passion for contributing to new ways of working and pushing beyond boundaries
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.
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