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Assistant Research Scientist II (Pharmacology)
  • Company: Exelixis, Inc.
  • Job ID: 2379
  • Functional Area: Drug Discovery
  • Position Type: Full-Time Regular
  • Experience Required: Not Indicated
  • Location: Alameda, CA
  • Department: Discovery
  • Education Required: Not Indicated
  • Relocation Provided:


Position Description:
The successful and highly motivated candidate will support the in vivo pharmacology research program and contribute to the multidisciplinary research team by designing and executing in vivo studies to determine pharmacokinetics and pharmacodynamics relationships and efficacy of optimized leads.

Position Requirements:
ESSENTIAL DUTIES AND RESPONSIBILITIES:
• Assist in the planning, design and implementation related to animal studies of pharmacokinetics, pharmacodynamics, and efficacy to evaluate and differentiate lead validation and lead optimization programs under general supervision
• Compliance with IACUC protocols and AAALAC regulations in conducting general research duties within assigned area of responsibility
• Prepare and organize data for presentation using analysis and visualization software; present data and reports on project status at individual, group, and departmental research meetings under general supervision
• Maintain familiarity with current scientific literature relevant to the research experiments or programs
• Maintain laboratory notebook in a complete, consistent, and concise manner in accordance with company intellectual property policies and practices
• Adhere to good health and safety practices and compliance with applicable EH&S rules, and participating in mandatory safety training programs

EDUCATION/EXPERIENCE/SKILLS:  
Education:
• BS in a relevant biological scientific discipline and two to four years of related experience; or,
• MS in a relevant biological scientific discipline and zero to two years of related experience
• Equivalent combination of education and experience

Experience:
• Proficiency with in vivo techniques including iv, ip, sc, po administration, and blood collection (tail vein, retroorbital, cardiac puncture, submandibular and etc.) is required
• Proficiency in animal tumor model development and execution including but not limited to syngeneic, xenograft and humanized mouse model is essential
• Good practice with in vitro sterile cell culture and scale-up for tumor implantation is required
• Ability to conduct organ harvesting; transcardial perfusion and fixation from small animals
• Adept at sample processing, homogenization, or generation of single-cell suspensions for ex vivo analysis
• Experience with immunology-related biological assays, flow cytometry, MSD and Luminex is a plus
• Excellent data analysis skills and experience with a variety of scientific software applications is preferred
• Proficiency with computers including MS Word, MS PowerPoint, and MS Excel is required
Knowledge/Skills/Abilities:
• General knowledge of pharmacokinetics, pharmacology and immunology techniques, theories, and practices
• General understanding of how the individual experiments fit within a larger research program to meet organizational goals
• General understanding and application of scientific principles, theories and concepts in field of specialty and other related disciplines
• Ability to perform in a fast-paced environment and be flexible and
• Ability to adapt to changing work conditions
• Must be self-motivated, able to multi-task and detail-oriented
• Strong communication skills, excellent work ethic, self-motivation, and ability to work effectively in a either a team environment or independently
• Understanding of regulatory requirements to run an in vivo facility
• Collaborate with other project team members

JOB COMPLEXITY:
• Work on problems of diverse scope where analysis of data requires evaluation of identifiable factors
• Exercise judgment within generally defined practices and policies in selecting methods and techniques for obtaining solutions
• Use professional concepts and company policies and procedures to solve a wide range of difficult problems in imaginative and practical ways

DISCLAIMER
The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.  It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.